Endocrine Abstracts

Aldosterone and cortisol coproducing adrenal adenoma is a rare type of primary aldosterone. Previous reports mostly describe single adrenocortical adenomas that simultaneously secrete aldosterone and cortisol. To date, only 7 cases of bilateral adrenocortical adenomas with independent functions of secreting different hormones have been reported in the published English literature. Here, we study an extremely rare case of a left adrenocortical adenoma secreting aldosterone and ...

A gentleman in his 70s with a background of atrial fibrillation, hypertension, and mesothelioma undergoing immunotherapy via Nivolumab and Ipilimumab, presented with general unwellness, fevers, confusion, and headaches. He had no prior endocrine history but was found to have significantly deranged thyroid function tests. He was treated for thyrotoxicosis and an impending thyroid storm with carbimazole. He remained treatment resistant for several days, with continuous delirium,...

Introduction: Patients with unilateral primary aldosteronism (PA) can be cured with adrenalectomy, and adrenal vein sampling (AVS) remains the gold-standard test. However, AVS is invasive, technically-challenging and criteria for determining lateralization differ between centres. 11C-Metomidate PET/CT (MTO) imaging offers a promising non-invasive alternative for identifying unilateral PA.Methods: All patients with confirmed primary aldosteronism who were...

The nicotinamide adenine dinucleotide (NAD+) dependent Poly-(ADP-ribosyl)polymerase 1 (PARP1) generates the post-translational modification ADP-Ribosylation (ADPR). Molecular studies have identified potential for NAD+ consuming enzymes to influence metabolic function. Given that PARP1 determines cellular NAD+ concentrations and ADPR shifts target protein activity, we sought to identify the molecular actions of PARP1 within skeletal muscle. Analysis of C2C12 lysates demonstrate...

Case: A 36-year-old gentleman presented with two month history of severe headaches, vomiting, polyuria and polydipsia. He reported profound episodic sweating especially on exertion and gradual weight loss. He was hypertensive (220/110 mmHg) at presentation. He had no palpitations, anxiety, dizziness, flushing or pallor. He had no diarrhoea or abdominal pain. His only family history was of Type 2 diabetes mellitus.Investigation: Biochemical investigations...

Background: Glucagon-like peptide-1 (GLP-1) concentrations are reduced by 20–50% in type 2 diabetes but studies in women with gestational diabetes mellitus (GDM) are inconclusive. Our aim was to study the GLP-1 profile during a glucose tolerance test (GTT) at GDM diagnosis and its relationship with insulin levels.Methods: A prospective study of selectively screened women was conducted. Plasma GLP-1, insulin and glucose were measured at 30-minute int...

Background: Hydrocortisone day curves (HCDCs) are commonly used to assess hydrocortisone replacement for patients with adrenal insufficiency (AI).Methods: HCDCs were obtained for 216 adrenally insufficient patients between 2004 and 2012 at Imperial College Healthcare NHS Trust. The area under the curve (AUC) was calculated for each patient’s day profile. Lipid profiles and glycated haemoglobin (HbA1c) values were recorded for each patient at both th...

Background: Glucocorticoid-induced osteoporosis is one of the major clinical concerns of long-term steroid treatment. Previous studies have shown that immunosuppressive doses of glucocorticoid can lead to osteoporosis. This study investigated whether there is a relationship between cortisol exposure and the development of osteoporosis in patients receiving replacement doses.Methods: Hydrocortisone day curves (HCDCs) performed a...

Background: Glucagon-like peptide-1 (GLP-1) concentrations are reduced by 20–50% in type 2 diabetes but studies in women with gestational diabetes mellitus (GDM) are inconclusive. Our aim was to study the GLP-1 profile during a glucose tolerance test (GTT) at GDM diagnosis and its relationship with insulin levels.Methods: A prospective study of selectively screened women was conducted. Plasma GLP-1, insulin and glucose were measured at 30-minute int...

Background: Hydrocortisone day curves (HCDCs) are commonly used to assess hydrocortisone replacement for patients with adrenal insufficiency (AI).Methods: HCDCs were obtained for 216 adrenally insufficient patients between 2004 and 2012 at Imperial College Healthcare NHS Trust. The area under the curve (AUC) was calculated for each patient’s day profile. Lipid profiles and glycated haemoglobin (HbA1c) values were recorded for each patient at both th...